Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation
Identifieur interne : 001A32 ( Main/Exploration ); précédent : 001A31; suivant : 001A33Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation
Auteurs : J. Madic [Pays-Bas] ; J. Magdalena [Pays-Bas] ; J. Quak [Pays-Bas] ; J. T. Van Oirschot [Pays-Bas]Source :
- Veterinary Immunology and Immunopathology [ 0165-2427 ] ; 1995.
English descriptors
- Teeft :
- Antibody, Antibody response, Antibody responses, Antibody titres, Bhvl, Calf, Control calves, Corticosteroid, Corticosteroid treatment, Excretion, First detection, Genital, Genital secretions, Higher increase, Igg2, Igg2 antibodies, Iggl, Immunology, Immunopathology, Iowa strain, Madic, Mucosal, Mucosal secretions, Nasal, Nasal secretions, Ocular, Ocular secretions, Primary infection, Reactivation, Reinfected, Reinfected calves, Reinfection, Secretion, Serum iggl, Titre, Veterinary immunology, Virus excretion.
Abstract
Abstract: Isotype-specific antibody responses to bovine herpesvirus 1 (BHV1) were measured in sera, nasal, ocular and genital secretions of calves that were reinfected with BHV1 and 6 weeks later treated with corticosteroids to reactivate putative latent virus. After reinfection and after reactivation, no BHV1-specific IgM antibody response was detected. The serum IgA response was only transiently detectable after reinfection and again appeared rapidly after reactivation in most calves. Most calves showed an increase in nasal and ocular IgA titres after reinfection and reactivation; some calves also had IgA antibodies in genital secretions. A salient finding was that after reinfection and reactivation more calves showed a serum IgA response than virus shedding or an increase in serum IgG1 or IgG2 titres. This suggests that the serum IgA response would be the most sensitive indicator to detect BHV1 reinfection and reactivation. No correlation was found between nasal IgA titre at the time of reinfection or corticosteroid treatment and the period of virus shedding, suggesting that nasal IgA does not play a major role in protection against reinfection with BHV1.
Url:
DOI: 10.1016/0165-2427(94)05379-7
Affiliations:
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Van Oirschot</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F01EF63AD069D1D99A80769C7E86D135D5710551</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0165-2427(94)05379-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-VLRJMQG5-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000548</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000548</idno><idno type="wicri:Area/Istex/Curation">000515</idno><idno type="wicri:Area/Istex/Checkpoint">000439</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000439</idno><idno type="wicri:doubleKey">0165-2427:1995:Madic J:isotype:specific:antibody</idno><idno type="wicri:Area/Main/Merge">001A48</idno><idno type="wicri:Area/Main/Curation">001A32</idno><idno type="wicri:Area/Main/Exploration">001A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation</title><author><name sortKey="Madic, J" sort="Madic, J" uniqKey="Madic J" first="J." last="Madic">J. Madic</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Animal Science and Health, Department of Bovine Virology, PO Box 65, 8200 AB Lelystad</wicri:regionArea><wicri:noRegion>8200 AB Lelystad</wicri:noRegion></affiliation></author><author><name sortKey="Magdalena, J" sort="Magdalena, J" uniqKey="Magdalena J" first="J." last="Magdalena">J. Magdalena</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Animal Science and Health, Department of Bovine Virology, PO Box 65, 8200 AB Lelystad</wicri:regionArea><wicri:noRegion>8200 AB Lelystad</wicri:noRegion></affiliation></author><author><name sortKey="Quak, J" sort="Quak, J" uniqKey="Quak J" first="J." last="Quak">J. Quak</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Animal Science and Health, Department of Bovine Virology, PO Box 65, 8200 AB Lelystad</wicri:regionArea><wicri:noRegion>8200 AB Lelystad</wicri:noRegion></affiliation></author><author><name sortKey="Van Oirschot, J T" sort="Van Oirschot, J T" uniqKey="Van Oirschot J" first="J. T." last="Van Oirschot">J. T. Van Oirschot</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute for Animal Science and Health, Department of Bovine Virology, PO Box 65, 8200 AB Lelystad</wicri:regionArea><wicri:noRegion>8200 AB Lelystad</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Veterinary Immunology and Immunopathology</title><title level="j" type="abbrev">VETIMM</title><idno type="ISSN">0165-2427</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="81">81</biblScope><biblScope unit="page" to="92">92</biblScope></imprint><idno type="ISSN">0165-2427</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2427</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody titres</term><term>Bhvl</term><term>Calf</term><term>Control calves</term><term>Corticosteroid</term><term>Corticosteroid treatment</term><term>Excretion</term><term>First detection</term><term>Genital</term><term>Genital secretions</term><term>Higher increase</term><term>Igg2</term><term>Igg2 antibodies</term><term>Iggl</term><term>Immunology</term><term>Immunopathology</term><term>Iowa strain</term><term>Madic</term><term>Mucosal</term><term>Mucosal secretions</term><term>Nasal</term><term>Nasal secretions</term><term>Ocular</term><term>Ocular secretions</term><term>Primary infection</term><term>Reactivation</term><term>Reinfected</term><term>Reinfected calves</term><term>Reinfection</term><term>Secretion</term><term>Serum iggl</term><term>Titre</term><term>Veterinary immunology</term><term>Virus excretion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Isotype-specific antibody responses to bovine herpesvirus 1 (BHV1) were measured in sera, nasal, ocular and genital secretions of calves that were reinfected with BHV1 and 6 weeks later treated with corticosteroids to reactivate putative latent virus. After reinfection and after reactivation, no BHV1-specific IgM antibody response was detected. The serum IgA response was only transiently detectable after reinfection and again appeared rapidly after reactivation in most calves. Most calves showed an increase in nasal and ocular IgA titres after reinfection and reactivation; some calves also had IgA antibodies in genital secretions. A salient finding was that after reinfection and reactivation more calves showed a serum IgA response than virus shedding or an increase in serum IgG1 or IgG2 titres. This suggests that the serum IgA response would be the most sensitive indicator to detect BHV1 reinfection and reactivation. No correlation was found between nasal IgA titre at the time of reinfection or corticosteroid treatment and the period of virus shedding, suggesting that nasal IgA does not play a major role in protection against reinfection with BHV1.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Madic, J" sort="Madic, J" uniqKey="Madic J" first="J." last="Madic">J. Madic</name></noRegion><name sortKey="Magdalena, J" sort="Magdalena, J" uniqKey="Magdalena J" first="J." last="Magdalena">J. Magdalena</name><name sortKey="Quak, J" sort="Quak, J" uniqKey="Quak J" first="J." last="Quak">J. Quak</name><name sortKey="Van Oirschot, J T" sort="Van Oirschot, J T" uniqKey="Van Oirschot J" first="J. T." last="Van Oirschot">J. T. Van Oirschot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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